Possible Mechanistic Link Between Stress And The Development Of Alzheimer Tangles

Subjecting mice to repeated emotional stress, the kind we experience in everyday life, may contribute to the accumulation of neurofibrillary tangles, one of the hallmarks of Alzheimer’s disease, report researchers at the Salk Institute for Biological Studies. While aging is still the greatest risk factor for Alzheimer’s disease, a number of studies have pointed to stress as a contributing factor.

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Corticotropin-Releasing Factor Receptors Differentially Regulate Stress-Induced Tau Phosphorylation
J. Neurosci., Jun 2007; 27: 6552 - 6562

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